Paraneoplastic cerebellar degeneration
نویسندگان
چکیده
منابع مشابه
[Paraneoplastic cerebellar degeneration].
Paraneoplastic cerebellar degeneration (PCD) is a rare manifestation of cancer, characterized clinically by subacute progressive ataxia, dysarthria and nystagmus. The pathological hallmark of PCD is a severe, diffuse loss of Purkinje cells. PCD occurs most frequently in association with small cell carcinoma of the lung and adenocarcinoma of the ovary, but it has also developed in patients with ...
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Neuroimaging is usually unremarkable in paraneoplastic cerebellar degeneration (PCD), at least in the early stages of the disease. A patient with proven PCD is reported in whom it could be shown that cerebellar atrophy evolved very rapidly and was present in early imaging studies. Even with the use of the whole spectrum of modern diagnostic tools, the underlying malignancy can be difficult to d...
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Anti-Hu antibody was first discovered in patients with paraneoplastic encephalomyelitis associated with small cell lung cancer (SCLC). This antibody recognises proteins comprised in the Hu family expressed by neuronal cells as well as SCLC. After the first report, anti-Hu antibody was found in other neoplasms including prostate and breast cancer, adrenal carcinoma, chondromyxosarcoma, neuroblas...
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Paraneoplastic cerebellar degeneration (PCD) is a rare neurological disorder characterized by a widespread loss of Purkinje cells associated with a progressive pancerebellar dysfunction. PCD often precedes the cancer diagnosis by months to years. Here, we report the case of a 64-year-old woman who developed PCD symptoms, associated with high levels of anti-Yo antibodies, one year after a previo...
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a Servicio de Neurología, Hospital Universitario La Fe, Valencia, Spain b Laboratorio de Neurología Experimental, Centro de Investigación, Hospital Universitario La Fe; Valencia, Spain and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) c Servicio de Neurología, Hospital Santa Maria del Rosell, Cartagena, Murcia, Spain d Servicio de Anatomía Patológica,...
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ژورنال
عنوان ژورنال: Journal of Neuro-Oncology
سال: 1984
ISSN: 0167-594X,1573-7373
DOI: 10.1007/bf00178121